Endocrine Abstracts

Introduction: Described in 1990 by N Sato et al., Takotsubo syndrome (TS) is an acute myocardial dysfunction with the development of heart failure.Objective: We present a description of the clinical case of ST after adrenalectomy for pheochromocytoma.Results: Pheochromocytoma of the left adrenal gland (methanephrine 553.7 pg/ml (norm <65) and plasma normmetanephrine 458 pg/ml (norm <196) was verified in 27-year-old...

Combination of coronary heart disease (CHD) with diabetes mellitus type 2 significantly increases the risk of left ventricular remodeling. The objective of the study was to determine the association of biomarkers of myocardial fibrosis with the level of glycaemia at CHD in patients with and without DM type 2.Methods: We have examined 104 patients with CHD of everage age 64.9±0.3 years old, 27 of them were with DM type 2; 77 patients were without DM ...

Objective: A diabetic state is causally related to heart failure (HF) which is a leading cause of mortality. Early detection of high-risk individuals is imperative for primary prevention. The aim of this study was to investigate the role of N-terminal pro-B-type Natriuretic Peptide (NT-proBNP) in patients with diabetes type 2 (DT2).Methods: We investigated 86 patients both sexes with DT2 aged 65.54±11.37 years (from 50 to 65 years) without clinical ...

Introduction: Atherosclerotic complications are the leading causes of morbidity and mortality among patients with DT2.Aim: To investigate the possible role of dyslipidaemia, hypertension and chronic kidney disease (CKD) on the characteristics of carotid atherosclerosis (presence of plaque, carotid IMT and total plaque area) in patients with DT2.Material and methods: Patients aged 60–75 years with DT2 were included in this stud...

Background: Polymorphisms in angiotensin-converting enzyme (ACE) gene and angiotensin II type 1 receptor (AGTR1) gene have been assessed in previously multiple studies for association with diabetic nephropathy (DN), but results are still controversial.Aim: The aim of our study was to find out the role of ACE (I/D) and AGTR1 (A1166C) in genetic susceptibility of diabetic nephropathy in Belarusian population.Methods: The present case...

Introduction: Diabetic nephropathy (DN) is one of the most serious chronic complications of diabetes mellitus characterized by persistent albuminuria, raised arterial blood pressure, a lowered glomerular filtration rate, and high-risk of cardiovascular morbidity and mortality. The vascular genes (Angiotensin-converting enzyme) ACE, and (aldosterone synthase) CYP11B2 are involved in alterations in vascular endothelium, and are suggested to play a role in the susceptibi...

Introduction: Gestational diabetes mellitus (GDM) has been recognized as a significant risk factor for metabolic syndrome. Emerging evidence suggests that leptin, an adipocyte-derived hormone, may have independent direct effects on both insulin secretion and action, in addition to its well documented effects on appetite and energy expenditure. The aim of this study was to evaluate fasting serum leptin concentration and its association to insulin resistance in women with gestat...